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Cited 34 time in webofscience Cited 37 time in scopus
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Next-generation biocontainment systems for engineered organisms

Title
Next-generation biocontainment systems for engineered organisms
Authors
LEE, JEONG WOOKChan, Clement T.Y.Slomovic, ShimynCollins, James J.
POSTECH Authors
LEE, JEONG WOOK
Date Issued
Jun-2018
Publisher
NATURE PUBLISHING GROUP
Abstract
The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms and transgenic materials. Emerging technologies in synthetic biology involving genetic circuit engineering, genome editing, and gene expression regulation have led to the development of novel biocontainment systems. In this perspective, we highlight recent advances in biocontainment and suggest a number of approaches for future development, which may be applied to overcome remaining challenges in safeguard implementation.
The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms and transgenic materials. Emerging technologies in synthetic biology involving genetic circuit engineering, genome editing, and gene expression regulation have led to the development of novel biocontainment systems. In this perspective, we highlight recent advances in biocontainment and suggest a number of approaches for future development, which may be applied to overcome remaining challenges in safeguard implementation.
The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms and transgenic materials. Emerging technologies in synthetic biology involving genetic circuit engineering, genome editing, and gene expression regulation have led to the development of novel biocontainment systems. In this perspective, we highlight recent advances in biocontainment and suggest a number of approaches for future development, which may be applied to overcome remaining challenges in safeguard implementation.
Keywords
synthetic DNA; Article; auxotrophy; biological functions; biosafety; cell free system; genetics; horizontal gene transfer; host; human; mutagenesis; priority journal; self concept; transgene; transgenic organism
URI
http://oasis.postech.ac.kr/handle/2014.oak/91956
DOI
10.1038/s41589-018-0056-x
ISSN
1552-4450
Article Type
Article
Citation
Nature Chemical Biology, vol. 14, no. 6, page. 530 - 537, 2018-06
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이정욱LEE, JEONG WOOK
Dept. of Chemical Enginrg
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