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Capicua suppresses hepatocellular carcinoma progression by controlling ETV4-MMP1 axis

Title
Capicua suppresses hepatocellular carcinoma progression by controlling ETV4-MMP1 axis
Authors
LEE, YOONTAEKIM, EUNJEONGKIM, DONG HYOLEE, JEON SOOJEE, HYUN YOEJONGMIN, PARKChang-Jin KimDongjun JeongKIM, SANGUK
POSTECH Authors
LEE, YOONTAEKIM, SANGUK
Date Issued
Jan-2018
Publisher
WILEY-BLACKWELL
Abstract
Hepatocellular carcinoma (HCC) is developed by multiple steps accompanying progressive alterations of gene expression, which leads to increased cell proliferation and malignancy. Although environmental factors and intracellular signaling pathways that are critical for HCC progression have been identified, gene expression changes and the related genetic factors contributing to HCC pathogenesis are still insufficiently understood. In this study, we identify a transcriptional repressor Capicua/CIC as a suppressor of HCC progression and a potential therapeutic target. Expression of CIC is posttranscriptionally reduced in HCC cells. CIC levels are correlated with survival rates in patients with HCC. CIC overexpression suppresses HCC cell proliferation and invasion, whereas loss of CIC exerts opposite effects in vivo as well as in vitro. The levels of PEA3 group genes, the best-known CIC target genes, are correlated with lethality in patients with HCC. Among the PEA3 group genes, ETV4 is the most significantly upregulated gene in CIC-deficient HCC cells, consequently promoting HCC progression. Furthermore, ETV4 induces expression of MMP1, the MMP gene highly relevant to HCC progression, in HCC cells, and knockdown of MMP1 completely blocks the CIC deficiency-induced HCC cell proliferation and invasion. CONCLUSION: Our study demonstrates that the CIC-ETV4-MMP1 axis is a novel regulatory module controlling HCC progression. This article is protected by copyright. All rights reserved.
URI
http://oasis.postech.ac.kr/handle/2014.oak/41188
DOI
10.1002/hep.29738
ISSN
0270-9139
Article Type
Article
Citation
HEPATOLOGY, 2018-01
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 KIM, SANGUK
Dept of Life Sciences
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