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dc.contributor.authorJEON, JAE HYUNGko
dc.contributor.authorSONG, MINHOko
dc.contributor.authorMOON, HYUNGSEOKko
dc.contributor.authorPARK, HYE YOONko
dc.date.accessioned2018-05-03T09:37:28Z-
dc.date.available2018-05-03T09:37:28Z-
dc.date.created2018-01-25-
dc.date.issued2018-01-
dc.identifier.citationNature Communications, v.9, no.1, pp.344-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://oasis.postech.ac.kr/handle/2014.oak/41037-
dc.description.abstractLocalization of messenger ribonucleoproteins (mRNPs) plays an essential role in the regulation of gene expression for long-term memory formation and neuronal development. Knowledge concerning the nature of neuronal mRNP transport is thus crucial for understanding how mRNPs are delivered to their target synapses. Here, we report experimental and theoretical evidence that the active transport dynamics of neuronal mRNPs, which is distinct from the previously reported motor-driven transport, follows an aging Levy walk. Such nonergodic, transient superdiffusion occurs because of two competing dynamic phases: the motor-involved ballistic run and static localization of mRNPs. Our proposed Levy walk model reproduces the experimentally extracted key dynamic characteristics of mRNPs with quantitative accuracy. Moreover, the aging status of mRNP particles in an experiment is inferred from the model. This study provides a predictive theoretical model for neuronal mRNP transport and offers insight into the active target search mechanism of mRNP particles in vivo.-
dc.description.abstractLocalization of messenger ribonucleoproteins (mRNPs) plays an essential role in the regulation of gene expression for long-term memory formation and neuronal development. Knowledge concerning the nature of neuronal mRNP transport is thus crucial for understanding how mRNPs are delivered to their target synapses. Here, we report experimental and theoretical evidence that the active transport dynamics of neuronal mRNPs, which is distinct from the previously reported motor-driven transport, follows an aging Levy walk. Such nonergodic, transient superdiffusion occurs because of two competing dynamic phases: the motor-involved ballistic run and static localization of mRNPs. Our proposed Levy walk model reproduces the experimentally extracted key dynamic characteristics of mRNPs with quantitative accuracy. Moreover, the aging status of mRNP particles in an experiment is inferred from the model. This study provides a predictive theoretical model for neuronal mRNP transport and offers insight into the active target search mechanism of mRNP particles in vivo.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectbeta actin-
dc.subjectkinesin-
dc.subjectmessenger RNA-
dc.subjectmolecular motor-
dc.subjectribonucleoprotein-
dc.subjectmessenger ribonucleoprotein-
dc.subjectribonucleoprotein-
dc.subjectexperimental study-
dc.subjectgene expression-
dc.subjectlaboratory method-
dc.subjectmemory-
dc.subjectnervous system-
dc.subjectprotein-
dc.subjectactive transport-
dc.subjectanimal experiment-
dc.subjectArticle-
dc.subjectcell aging-
dc.subjectcell body-
dc.subjectcontrolled study-
dc.subjectlong term memory-
dc.subjectmicrotubule-
dc.subjectmolecular dynamics-
dc.subjectmouse-
dc.subjectnerve cell-
dc.subjectnerve cell culture-
dc.subjectnonhuman-
dc.subjectparticle size-
dc.subjectprotein localization-
dc.subjectRNA transport-
dc.subjecttheoretical model-
dc.subjectanimal-
dc.subjectgene expression-
dc.subjecthippocampus-
dc.subjectmetabolism-
dc.subjectnerve cell-
dc.subjecttransport at the cellular level-
dc.subjectAnimals-
dc.subjectBiological Transport-
dc.subjectGene Expression-
dc.subjectHippocampus-
dc.subjectMemory, Long-Term-
dc.subjectMice-
dc.subjectNeurons-
dc.subjectRibonucleoproteins-
dc.titleNeuronal messenger ribonucleoprotein transport follows an aging Lévy walk-
dc.typeArticle-
dc.identifier.doi10.1038/s41467-017-02700-z-
dc.type.rimsART-
dc.contributor.localauthorJEON, JAE HYUNG-
dc.contributor.nonIdAuthorSONG, MINHO-
dc.contributor.nonIdAuthorMOON, HYUNGSEOK-
dc.contributor.nonIdAuthorPARK, HYE YOON-
dc.identifier.wosid000423155700002-
dc.date.tcdate2019-02-01-
dc.citation.number1-
dc.citation.startPage344-
dc.citation.titleNature Communications-
dc.citation.volume9-
dc.identifier.scopusid2-s2.0-85041046078-
dc.description.journalClass1-
dc.description.wostc11-

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 JEON, JAE HYUNG
Dept of Physics
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