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Neuronal messenger ribonucleoprotein transport follows an aging Lévy walk

Title
Neuronal messenger ribonucleoprotein transport follows an aging Lévy walk
Authors
JEON, JAE HYUNGSONG, MINHOMOON, HYUNGSEOKPARK, HYE YOON
POSTECH Authors
JEON, JAE HYUNG
Date Issued
Jan-2018
Publisher
NATURE PUBLISHING GROUP
Abstract
Localization of messenger ribonucleoproteins (mRNPs) plays an essential role in the regulation of gene expression for long-term memory formation and neuronal development. Knowledge concerning the nature of neuronal mRNP transport is thus crucial for understanding how mRNPs are delivered to their target synapses. Here, we report experimental and theoretical evidence that the active transport dynamics of neuronal mRNPs, which is distinct from the previously reported motor-driven transport, follows an aging Levy walk. Such nonergodic, transient superdiffusion occurs because of two competing dynamic phases: the motor-involved ballistic run and static localization of mRNPs. Our proposed Levy walk model reproduces the experimentally extracted key dynamic characteristics of mRNPs with quantitative accuracy. Moreover, the aging status of mRNP particles in an experiment is inferred from the model. This study provides a predictive theoretical model for neuronal mRNP transport and offers insight into the active target search mechanism of mRNP particles in vivo.
Localization of messenger ribonucleoproteins (mRNPs) plays an essential role in the regulation of gene expression for long-term memory formation and neuronal development. Knowledge concerning the nature of neuronal mRNP transport is thus crucial for understanding how mRNPs are delivered to their target synapses. Here, we report experimental and theoretical evidence that the active transport dynamics of neuronal mRNPs, which is distinct from the previously reported motor-driven transport, follows an aging Levy walk. Such nonergodic, transient superdiffusion occurs because of two competing dynamic phases: the motor-involved ballistic run and static localization of mRNPs. Our proposed Levy walk model reproduces the experimentally extracted key dynamic characteristics of mRNPs with quantitative accuracy. Moreover, the aging status of mRNP particles in an experiment is inferred from the model. This study provides a predictive theoretical model for neuronal mRNP transport and offers insight into the active target search mechanism of mRNP particles in vivo.
Keywords
beta actin; kinesin; messenger RNA; molecular motor; ribonucleoprotein; messenger ribonucleoprotein; ribonucleoprotein; experimental study; gene expression; laboratory method; memory; nervous system; protein; active transport; animal experiment; Article; cell aging; cell body; controlled study; long term memory; microtubule; molecular dynamics; mouse; nerve cell; nerve cell culture; nonhuman; particle size; protein localization; RNA transport; theoretical model; animal; gene expression; hippocampus; metabolism; nerve cell; transport at the cellular level; Animals; Biological Transport; Gene Expression; Hippocampus; Memory, Long-Term; Mice; Neurons; Ribonucleoproteins
URI
http://oasis.postech.ac.kr/handle/2014.oak/41037
DOI
10.1038/s41467-017-02700-z
ISSN
2041-1723
Article Type
Article
Citation
Nature Communications, vol. 9, no. 1, page. 344, 2018-01
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 JEON, JAE HYUNG
Dept of Physics
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