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dc.contributor.authorJeon, O-
dc.contributor.authorSong, SJ-
dc.contributor.authorLee, KJ-
dc.contributor.authorPark, MH-
dc.contributor.authorLee, SH-
dc.contributor.authorHahn, SK-
dc.contributor.authorKim, S-
dc.contributor.authorKim, BS-
dc.contributor.author한세광-
dc.date.accessioned2016-04-01T09:06:59Z-
dc.date.available2016-04-01T09:06:59Z-
dc.date.issued2007-01-
dc.identifier.citationCARBOHYDRATE POLYMERS-
dc.identifier.citationv.70-
dc.identifier.citationno.3-
dc.identifier.citationpp.251-257-
dc.identifier.issn0144-8617-
dc.identifier.other2007-OAK-0000010819-
dc.identifier.urihttp://oasis.postech.ac.kr/handle/2014.oak/29483-
dc.description.abstractThe effect of cross-linking density of hyaluronic acid (HA) hydrogels on mechanical properties and degradation behaviors has been investigated. HA hydrogels were prepared by the covalent cross-linking of HA with poly(ethylene glycol)-diamine with two different molecular weights at various cross-linking densities. The elastic modulus increased gradually as the theoretical cross-linking density of HA hydrogels increased from 0% to 20%. However, as the theoretical cross-linking density increased above 20%, the elastic modulus decreased. At a theoretical cross-linking density of 20%, the elastic modulus increased as the molecular weight of the cross-linking molecule decreased. In vitro degradation rates of HA hydrogels decreased as the molecular weight of the cross-linking molecule decreased at a theoretical cross-linking density of 20%. The degradation rate of the cross-linked HA hydrogels decreased with increases in the theoretical cross-linking density from 0% to 20%. However, there was no significant difference in the degradation rate as the theoretical cross-linking density increased above 30%. With controllable mechanical properties and degradation rates, the developed HA hydrogels would be further investigated for various medical applications. (c) 2007 Elsevier Ltd. All rights reserved.-
dc.description.statementofresponsibilityX-
dc.publisherELSEVIER SCI LTD-
dc.subjectcross-linking-
dc.subjectdegradation-
dc.subjectelastic modulus-
dc.subjecthyaluronic acid-
dc.subjecthydrogel-
dc.subjectpoly(ethylene glycol)-
dc.subjectFIBROBLAST-GROWTH-FACTOR-
dc.subjectFUNCTIONALIZED DERIVATIVES-
dc.subjectFIBRIN MATRIX-
dc.subjectTRANSPLANTATION-
dc.subjectBIOMATERIALS-
dc.subjectRIGIDITY-
dc.subjectALGINATE-
dc.subjectRELEASE-
dc.subjectFILMS-
dc.titleMechanical properties and degradation behaviors of hyaluronic acid hydrogels cross-linked at various cross-linking densities-
dc.typeARTICLE-
dc.contributor.college신소재공학과-
dc.identifier.doi10.1016/J.CARBPOL.20-
dc.author.googleJeon, O-
dc.author.googleSong, SJ-
dc.author.googleLee, KJ-
dc.author.googlePark, MH-
dc.author.googleLee, SH-
dc.author.googleHahn, SK-
dc.author.googleKim, S-
dc.author.googleKim, BS-
dc.relation.volume70-
dc.relation.issue3-
dc.relation.startpage251-
dc.relation.lastpage257-
dc.contributor.id10149037-
dc.publisher.locationUK-
dc.relation.journalCARBOHYDRATE POLYMERS-
dc.relation.indexSCI급, SCOPUS 등재논문-
dc.relation.sciSCI-
dc.collections.nameJournal Papers-
dc.type.rimsART-

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