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Mechanical properties and degradation behaviors of hyaluronic acid hydrogels cross-linked at various cross-linking densities

Title
Mechanical properties and degradation behaviors of hyaluronic acid hydrogels cross-linked at various cross-linking densities
Authors
Jeon, OSong, SJLee, KJPark, MHLee, SHHahn, SKKim, SKim, BS한세광
Date Issued
Jan-2007
Publisher
ELSEVIER SCI LTD
Abstract
The effect of cross-linking density of hyaluronic acid (HA) hydrogels on mechanical properties and degradation behaviors has been investigated. HA hydrogels were prepared by the covalent cross-linking of HA with poly(ethylene glycol)-diamine with two different molecular weights at various cross-linking densities. The elastic modulus increased gradually as the theoretical cross-linking density of HA hydrogels increased from 0% to 20%. However, as the theoretical cross-linking density increased above 20%, the elastic modulus decreased. At a theoretical cross-linking density of 20%, the elastic modulus increased as the molecular weight of the cross-linking molecule decreased. In vitro degradation rates of HA hydrogels decreased as the molecular weight of the cross-linking molecule decreased at a theoretical cross-linking density of 20%. The degradation rate of the cross-linked HA hydrogels decreased with increases in the theoretical cross-linking density from 0% to 20%. However, there was no significant difference in the degradation rate as the theoretical cross-linking density increased above 30%. With controllable mechanical properties and degradation rates, the developed HA hydrogels would be further investigated for various medical applications. (c) 2007 Elsevier Ltd. All rights reserved.
Keywords
cross-linking; degradation; elastic modulus; hyaluronic acid; hydrogel; poly(ethylene glycol); FIBROBLAST-GROWTH-FACTOR; FUNCTIONALIZED DERIVATIVES; FIBRIN MATRIX; TRANSPLANTATION; BIOMATERIALS; RIGIDITY; ALGINATE; RELEASE; FILMS
URI
http://oasis.postech.ac.kr/handle/2014.oak/29483
DOI
10.1016/J.CARBPOL.20
ISSN
0144-8617
Article Type
ARTICLE
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