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Guided bone regeneration by poly(lactic-co-glycolic acid) grafted hyaluronic acid bi-layer films for periodontal barrier applications

Title
Guided bone regeneration by poly(lactic-co-glycolic acid) grafted hyaluronic acid bi-layer films for periodontal barrier applications
Authors
Park, JKYeom, JOh, EJReddy, MKim, JYCho, DWLim, HPKim, NSPark, SWShin, HIYang, DJPark, KBHahn, SK
POSTECH Authors
Hahn, SK
Date Issued
Nov-2009
Publisher
ELSEVIER SCI LTD
Abstract
A novel protocol for the synthesis of biocompatible and degradation controlled poly(lactic-co-glycolic acid) grafted hyaluronic acid (HA-PLGA) was successfully developed for periodontal barrier applications. HA was chemically modified with adipic acid dihydrazide (ADH) in the mixed solvent of water and ethanol, which resulted in a high degree of HA modification up to 85 mol.%. The stability of HA-ADH to enzymatic degradation by hyaluronidase increased with ADH content in HA-ADH. When the ADH content in HA-ADH was higher than 80 mol.%, HA-ADH became soluble in dimethyl sulfoxide and could be grafted to the activated PLGA with N,N'-dicyclohexyl carbodiimide and N-hydroxysuccinimide. The resulting HA-PLGA was used for the preparation of biphasic periodontal barrier membranes in chloroform. According to in vitro hydrolytic degradation tests in phosphate buffered saline, HA-PLGA/PLGA blend film with a weight ratio of 1/2 degraded relatively slowly compared to PLGA film and HA coated PLGA film. Four different sa I triples of a control, OSSIX (TM) membrane, PLGA film, and HA-PLGA/PLGA film were assessed as periodontal barrier membranes for the calvarial critical size bone defects in SD rats. Histological and histomorphometric analyses revealed that HA-PLGA/PLGA film resulted in the most effective bone regeneration compared to other samples with a regenerated bone area of 63.1% covering the bone defect area. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Keywords
Hyaluronic acid; Poly(lactic-co-glycolic acid); Periodontal barrier membrane; Controlled degradation; Bone regeneration; SUSTAINED-RELEASE FORMULATION; TISSUE REGENERATION; COLLAGEN MEMBRANE; IN-VIVO; ATTACHMENT FORMATION; DRUG-DELIVERY; QUANTUM DOTS; DEFECTS; HYDROGELS
URI
http://oasis.postech.ac.kr/handle/2014.oak/27637
DOI
10.1016/J.ACTBIO.200
ISSN
1742-7061
Article Type
Article
Citation
ACTA BIOMATERIALIA, vol. 5, no. 9, page. 3394 - 3403, 2009-11
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 HAHN, SEI KWANG
Dept of Materials Science & Enginrg
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