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Vascular Endothelial Growth Factor Is a Key Mediator in the Development of T Cell Priming and Its Polarization to Type 1 and Type 17 T Helper Cells in the Airways

Title
Vascular Endothelial Growth Factor Is a Key Mediator in the Development of T Cell Priming and Its Polarization to Type 1 and Type 17 T Helper Cells in the Airways
Authors
Kim, YSHong, SWChoi, JPShin, TSMoon, HGChoi, EJJeon, SGOh, SYGho, YSZhu, ZKim, YK
POSTECH Authors
Gho, YSKim, YK
Date Issued
Oct-2009
Publisher
AMER ASSOC IMMUNOLOGISTS
Abstract
Chronic inflammatory airway diseases including asthma are characterized by immune dysfunction to inhaled allergens. Our previous studies demonstrated that T cell priming to inhaled allergens requires LPS, which is ubiquitously present in household dust allergens. In this study, we evaluated the role of vascular endothelial growth factor (VEGF) in the development of T cell priming and its polarization to Th1 or Th17 cells when exposed to LPS-contaminated allergens. An asthma mouse model was induced by airway sensitization with LPS-contaminated allergens and then challenged with allergens alone. Therapeutic intervention was performed during allergen sensitization. The present study showed that lung inflammation induced by sensitization with LPS-contaminated allergens was decreased in mice with homozygous disruption of the IL-17 gene
in addition, allergen-specific Th17 immune response was abolished in IL-6 knockout mice. Meanwhile, in vivo production of VEGF was up-regulated by airway exposure of LPS. In addition, airway sensitization of allergen plus recombinant VEGF induced both type I and type 17 Th cell (Th1 and Th17) responses. Th1 and Th17 responses induced by airway sensitization with LPS-contaminated allergens were blocked by treatment with a pan-VEGF receptor (VEGFR
VEGFR-1 plus VEGFR-2) inhibitor during sensitization. These effects were accompanied by inhibition of the production of Th1 and Th17 polarizing cytokines, IL-12p70 and IL-6, respectively. These findings indicate that VEGF produced by LPS plays a key role inactivation of naive T cells and subsequent polarization to Th1 and Th17 cells. The Journal of Immunology, 2009, 183: 5113-5120.
Keywords
EXPERIMENTAL ASTHMA; INTERFERON-GAMMA; FACTOR VEGF; INFLAMMATION; ENDOTOXIN; EXPOSURE; IL-23; LUNG; INTERLEUKIN-17; SENSITIZATION
URI
http://oasis.postech.ac.kr/handle/2014.oak/26117
DOI
10.4049/JIMMUNOL.0901566
ISSN
0022-1767
Article Type
Article
Citation
JOURNAL OF IMMUNOLOGY, vol. 183, no. 8, page. 5113 - 5120, 2009-10
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 GHO, YONG SONG
Dept of Life Sciences
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