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Cited 7 time in webofscience Cited 6 time in scopus
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Aspirin attenuates the anti-inflammatory effects of theophylline via inhibition of cAMP production in mice with non-eosinophilic asthma

Title
Aspirin attenuates the anti-inflammatory effects of theophylline via inhibition of cAMP production in mice with non-eosinophilic asthma
Authors
Moon, HGKim, YSChoi, JPChoi, DSYoon, CMJeon, SGGho, YSKim, YK
POSTECH Authors
Gho, YSKim, YK
Date Issued
Jan-2010
Publisher
Nature Publishing Group
Abstract
Theophylline is commonly used to treat severe asthma and chronic obstructive pulmonary disease (COPD) characterized by non-eosinophilic inflammation. Acetyl salicylic acid (ASA) is one of the most widely used medications worldwide, but up to 20% of patients with asthma experience aggravated respiratory symptoms after taking ASA. Here we evaluated the adverse effect of ASA on the therapeutic effect of theophylline in mice with non-eosinophilic asthma. A non-eosinophilic asthma mouse model was induced by airway sensitization with lipopolysaccharide-containing allergen and then challenged with allergen alone. Therapeutic intervention was performed during allergen challenge. Theophylline inhibited lung inflammation partly induced by TO immune response. ASA attenuated the beneficial effects of theophylline. However, co-administration of the ASA metabolite salicylic acid (SA) showed no attenuating effect on theophylline treatment. The therapeutic effect of theophylline was associated with increase in cAMP levels, which was blocked by co-treatment of theophylline and ASA. ASA co-treatment also attenuated the anti-inflammatory effects of a specific phosphodiesterase 4 inhibitor. These results demonstrate that ASA reverses anti-inflammatory effects of theophylline, and that ASA exerts its adverse effects through the inhibition of cAMP production. Our data suggest that ASA reverses lung inflammation in patients taking theophylline, although clinical evidence will be needed.
URI
http://oasis.postech.ac.kr/handle/2014.oak/26009
DOI
10.3858/EMM.2010.42.1.005
ISSN
1226-3613
Article Type
Article
Citation
EXPERIMENTAL AND MOLECULAR MEDICINE, vol. 42, no. 1, page. 47 - 60, 2010-01
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 GHO, YONG SONG
Dept of Life Sciences
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