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Cited 70 time in webofscience Cited 78 time in scopus
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dc.contributor.authorPark, KSko
dc.contributor.authorChoi, KHko
dc.contributor.authorKim, YSko
dc.contributor.authorHong, BSko
dc.contributor.authorKim, OYko
dc.contributor.authorKim, JHko
dc.contributor.authorYoon, CMko
dc.contributor.authorKoh, GYko
dc.contributor.authorKim, YKko
dc.contributor.authorGho, YSko
dc.date.available2016-04-01T02:44:02Z-
dc.date.created2010-11-24-
dc.date.issued2010-06-
dc.identifier.citationPLOS ONE, v.5, no.6, pp.E11334-
dc.identifier.issn1932-6203-
dc.identifier.other2010-OAK-0000021843-
dc.identifier.urihttp://oasis.postech.ac.kr/handle/2014.oak/25671-
dc.description.abstractSepsis, characterized by a systemic inflammatory state that is usually related to Gram-negative bacterial infection, is a leading cause of death worldwide. Although the annual incidence of sepsis is still rising, the exact cause of Gram-negative bacteria-associated sepsis is not clear. Outer membrane vesicles (OMVs), constitutively secreted from Gram-negative bacteria, are nano-sized spherical bilayered proteolipids. Using a mouse model, we showed that intraperitoneal injection of OMVs derived from intestinal Escherichia coli induced lethality. Furthermore, OMVs induced host responses which resemble a clinically relevant condition like sepsis that was characterized by piloerection, eye exudates, hypothermia, tachypnea, leukopenia, disseminated intravascular coagulation, dysfunction of the lungs, hypotension, and systemic induction of tumor necrosis factor-alpha and interleukin-6. Our study revealed a previously unidentified causative microbial signal in the pathogenesis of sepsis, suggesting OMVs as a new therapeutic target to prevent and/or treat severe sepsis caused by Gram-negative bacterial infection.-
dc.description.statementofresponsibilityX-
dc.languageEnglish-
dc.publisherPUBLIC LIBRARY SCIENCE-
dc.titleOuter Membrane Vesicles Derived from Escherichia coli Induce Systemic Inflammatory Response Syndrome-
dc.typeArticle-
dc.contributor.college생명과학과-
dc.identifier.doi10.1371/JOURNAL.PONE.0011334-
dc.author.googlePark, KS-
dc.author.googleChoi, KH-
dc.author.googleKim, YS-
dc.author.googleHong, BS-
dc.author.googleKim, OY-
dc.author.googleKim, JH-
dc.author.googleYoon, CM-
dc.author.googleKoh, GY-
dc.author.googleKim, YK-
dc.author.googleGho, YS-
dc.relation.volume5-
dc.relation.issue6-
dc.relation.startpageE11334-
dc.contributor.id10138843-
dc.publisher.locationUS-
dc.relation.journalPLOS ONE-
dc.relation.indexSCI급, SCOPUS 등재논문-
dc.relation.sciSCIE-
dc.collections.nameJournal Papers-
dc.type.rimsART-
dc.contributor.localauthorGho, YS-
dc.contributor.nonIdAuthorPark, KS-
dc.contributor.nonIdAuthorChoi, KH-
dc.contributor.nonIdAuthorKim, YS-
dc.contributor.nonIdAuthorHong, BS-
dc.contributor.nonIdAuthorKim, OY-
dc.contributor.nonIdAuthorKim, JH-
dc.contributor.nonIdAuthorYoon, CM-
dc.contributor.nonIdAuthorKoh, GY-
dc.contributor.nonIdAuthorKim, YK-
dc.identifier.wosid000279259900007-
dc.date.tcdate2019-02-01-
dc.citation.number6-
dc.citation.startPageE11334-
dc.citation.titlePLOS ONE-
dc.citation.volume5-
dc.identifier.localId0000021843-
dc.identifier.localId0000021974-
dc.identifier.scopusid2-s2.0-77955321899-
dc.description.journalClass1-
dc.description.wostc58-
dc.description.scptc52*
dc.date.scptcdate2018-05-121*

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Dept of Life Sciences
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