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Cited 69 time in webofscience Cited 78 time in scopus
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Outer Membrane Vesicles Derived from Escherichia coli Induce Systemic Inflammatory Response Syndrome

Title
Outer Membrane Vesicles Derived from Escherichia coli Induce Systemic Inflammatory Response Syndrome
Authors
Park, KSChoi, KHKim, YSHong, BSKim, OYKim, JHYoon, CMKoh, GYKim, YKGho, YS
POSTECH Authors
Gho, YS
Date Issued
Jun-2010
Publisher
PUBLIC LIBRARY SCIENCE
Abstract
Sepsis, characterized by a systemic inflammatory state that is usually related to Gram-negative bacterial infection, is a leading cause of death worldwide. Although the annual incidence of sepsis is still rising, the exact cause of Gram-negative bacteria-associated sepsis is not clear. Outer membrane vesicles (OMVs), constitutively secreted from Gram-negative bacteria, are nano-sized spherical bilayered proteolipids. Using a mouse model, we showed that intraperitoneal injection of OMVs derived from intestinal Escherichia coli induced lethality. Furthermore, OMVs induced host responses which resemble a clinically relevant condition like sepsis that was characterized by piloerection, eye exudates, hypothermia, tachypnea, leukopenia, disseminated intravascular coagulation, dysfunction of the lungs, hypotension, and systemic induction of tumor necrosis factor-alpha and interleukin-6. Our study revealed a previously unidentified causative microbial signal in the pathogenesis of sepsis, suggesting OMVs as a new therapeutic target to prevent and/or treat severe sepsis caused by Gram-negative bacterial infection.
URI
http://oasis.postech.ac.kr/handle/2014.oak/25671
DOI
10.1371/JOURNAL.PONE.0011334
ISSN
1932-6203
Article Type
Article
Citation
PLOS ONE, vol. 5, no. 6, page. E11334, 2010-06
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 GHO, YONG SONG
Dept of Life Sciences
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