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The SH3 domain of phospholipase C-gamma 1 associates with Shc

Title
The SH3 domain of phospholipase C-gamma 1 associates with Shc
Authors
Kim, MJHwang, JIChang, JSRyu, SHSuh, PG
POSTECH Authors
Ryu, SH
Date Issued
Jan-1999
Publisher
SPRINGER-VERLAG SINGAPORE PTE LTD
Abstract
The Shc3 domain of PLC-gamma 1 has been known to induce DNA synthesis. However, little is known about the putative effector proteins that associate with the domain, In this report, we provide evidence that the SH3 domain of PLC-gamma 1 associates with Shc, which has been implicated in the activation of p21Ras in response to many growth factors. The association between Shc and PLC-gamma 1 is enhanced either by nu-Src-induced transformation or EGF-stimulation in vivo and in vitro. Furthermore, from transient expression studies with COS-7 cells, we show that the SH3 domain of PLC-gamma 1 is required for association with Shc in vivo, whereas tyrosyl phosphorylation of PLC-gamma 1 is not. Taken together, we suggest that Shc might be involved in the PLC-gamma 1-mediated signaling pathway.
Keywords
GST; PLC-gamma 1; protein-protein interaction; SH3 domain; Shc; DNA-SYNTHESIS; ELEVATED CONTENT; B-LYMPHOCYTES; C ISOZYMES; PROTEIN; PLC-GAMMA-1; HOMOLOGY; RAS; SRC; PHOSPHORYLATION
URI
http://oasis.postech.ac.kr/handle/2014.oak/20462
ISSN
1225-8687
Article Type
Article
Citation
JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 32, no. 2, page. 119 - 126, 1999-01
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 RYU, SUNG HO
Dept of Life Sciences
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