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Reinforcing Polycaprolactone (PCL) nanofiber with a recombinant mussel adhesive protein-1 (Rmfp-1)

Title
Reinforcing Polycaprolactone (PCL) nanofiber with a recombinant mussel adhesive protein-1 (Rmfp-1)
Authors
김상식
Date Issued
2013
Publisher
포항공과대학교
Abstract
Electrospun Poly (ε-caprolactone) (PCL) nanofibers have been widely used for tissue engineering applications. However, the poor mechanical properties of PCL nanofibers limit their further utilization in hard tissue engineering. To improve the mechanical properties of PCL nanofibers, we fabricated nanofiber mats by blending PCL and recombinant mussel coating protein (Rmfp-1) to mimic the protective coating of mussels (Mytilus species) which is hard (~comparable to epoxy resin) yet flexible(ε~>70%). The stiffness of PCL/Rmfp-1 nanofiber mat increases linearly with the concentration of DOPA-Fe3+ complex which is a key component of the mussel protective coating in mfp-1. Mimicking the mussel protective coating is a new strategy to enhance the mechanical properties of biomedical materials
URI
http://postech.dcollection.net/jsp/common/DcLoOrgPer.jsp?sItemId=000001627736
http://oasis.postech.ac.kr/handle/2014.oak/2003
Article Type
Thesis
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