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Cited 209 time in webofscience Cited 242 time in scopus
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Engineering tolerance and accumulation of lead and cadmium in transgenic plants

Title
Engineering tolerance and accumulation of lead and cadmium in transgenic plants
Authors
Song, WYSohn, EJMartinoia, ELee, YJYang, YYJasinski, MForestier, CHwang, ILee, Y
POSTECH Authors
Hwang, ILee, Y
Date Issued
Jan-2003
Publisher
NATURE PUBLISHING GROUP
Abstract
We have studied the utility of the yeast protein YCF1, which detoxifies cadmium by transporting it into vacuoles, for the remediation of lead and cadmium contamination. We found that the yeast YCF1-deletion mutant DTY167 was hypersensitive to Pb(II) as compared with wild-type yeast. DTY167 cells overexpressing YCF1 were more resistant to Pb( II) and Cd( II) than were wild-type cells, and accumulated more lead and cadmium. Analysis of transgenic Arabidopsis thaliana plants overexpressing YCF1 showed that YCF1 is functionally active and that the plants have enhanced tolerance of Pb( II) and Cd( II) and accumulated greater amounts of these metals. These results suggest that transgenic plants expressing YCF1 may be useful for phytoremediation of lead and cadmium.
Keywords
RESISTANCE-ASSOCIATED PROTEIN; SACCHAROMYCES-CEREVISIAE; ARABIDOPSIS-THALIANA; INDIAN MUSTARD; YEAST; GLUTATHIONE; TRANSPORT; GENE; PHYTOREMEDIATION; DETOXIFICATION
URI
http://oasis.postech.ac.kr/handle/2014.oak/18425
DOI
10.1038/NBT850
ISSN
1087-0156
Article Type
Article
Citation
NATURE BIOTECHNOLOGY, vol. 21, no. 8, page. 914 - 919, 2003-01
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 HWANG, INHWAN
Div of Integrative Biosci & Biotech
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