Open Access System for Information Sharing

Login Library

 

Article
Cited 113 time in webofscience Cited 105 time in scopus
Metadata Downloads

T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation

Title
T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation
Authors
Kataru, RPKim, HJang, CChoi, DKKoh, BIKim, MGollamudi, SKim, YKLee, SHKoh, GY
POSTECH Authors
Kim, YKKoh, GY
Date Issued
Jan-2011
Publisher
CELL PRESS
Abstract
Lymph node lymphatic vessels (LNLVs) serve as a conduit to drain antigens from peripheral tissues to within the lymph nodes. LNLV density is known to be positively regulated by vascular endothelial growth factors secreted by B cells, macrophages, and dendritic cells (DCs). Here, we show that LNLV formation was negatively regulated by T cells. In both steady and inflammatory states, the density of LNLVs was increased in the absence of T cells but decreased when T cells were restored. Interferon-gamma secretion by T cells suppressed lymphatic-specific genes in lymphatic endothelial cells and consequently caused marked reduction in LNLV formation. When T cells were depleted, recruitment of antigen-carrying DCs to LNs was augmented, reflecting a compensatory mechanism for antigen presentation to T cells through increased LNLVs. Thus, T cells maintain the homeostatic balance of LNLV density through a negative paracrine action of interferon-gamma.
URI
http://oasis.postech.ac.kr/handle/2014.oak/16738
DOI
10.1016/J.IMMUNI.2010.12.016
ISSN
1074-7613
Article Type
Article
Citation
IMMUNITY, vol. 34, no. 1, page. 96 - 107, 2011-01
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

 KOH, GOU YOUNG
Div of Molecular & Life Science
Read more

Views & Downloads

Browse