DC Field | Value | Language |
---|---|---|
dc.contributor.author | YOUNG RAN HA | - |
dc.contributor.author | Choi, YW | - |
dc.contributor.author | Lee, SJ | - |
dc.date.accessioned | 2016-03-31T09:05:25Z | - |
dc.date.available | 2016-03-31T09:05:25Z | - |
dc.date.created | 2012-03-25 | - |
dc.date.issued | 2011-12 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.other | 2011-OAK-0000025205 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/16614 | - |
dc.description.abstract | Plectin, a linker protein that organizes the cytoskeleton, is critical for cell migration and wound healing. It is specifically expressed in epithelial cells, muscles, and other tissues. Numerous studies have shown that curcumin (diferuloylmethane) has anti-cancer potential. Curcumin can inhibit cancer cell migration and invasion through various signaling pathways. In this study, the down-regulation of plectin expression by siRNA was observed to induce the migration and invasion of human breast and lung cancer cell lines. Interestingly, the down-regulation of plectin expression by siRNA reversed the curcumin-induced anti-migration and anti-invasion effects in both cancer cell lines while alpha-tocopherol and genistein inhibited knockdown of plectin induced cancer cell migration. Curcumin did not affect the expression of plectin; however, alpha-tocopherol and genistein inhibited migration in plectin down-regulated cancer cells. These findings support the novel role of plectin and its effect on the anti-migration and anti-invasion potential of curcumin. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.subject | plectin | - |
dc.subject | curcumin | - |
dc.subject | anti-oxidant | - |
dc.subject | tumor migration | - |
dc.subject | tumor invasion | - |
dc.subject | CANCER-CELL INVASION | - |
dc.subject | PANCREATIC-CANCER | - |
dc.subject | PROSTATE-CANCER | - |
dc.subject | SUPPRESSOR HLJ1 | - |
dc.subject | BREAST-CANCER | - |
dc.subject | GENE-PRODUCTS | - |
dc.subject | PROLIFERATION | - |
dc.subject | METASTASIS | - |
dc.subject | EXPRESSION | - |
dc.subject | KINASE | - |
dc.title | Critical role of plectin in anti-migration potential of curcumin | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1007/S10068-011-0223-2 | - |
dc.author.google | Ha, YR | - |
dc.author.google | Choi, YW | - |
dc.author.google | Lee, SJ | - |
dc.relation.volume | 20 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 1615 | - |
dc.relation.lastpage | 1624 | - |
dc.contributor.id | 10054593 | - |
dc.relation.journal | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, v.20, no.6, pp.1615 - 1624 | - |
dc.identifier.wosid | 000298504800022 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1624 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1615 | - |
dc.citation.title | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.volume | 20 | - |
dc.contributor.affiliatedAuthor | Lee, SJ | - |
dc.identifier.scopusid | 2-s2.0-84862937418 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 5 | - |
dc.description.scptc | 4 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | plectin | - |
dc.subject.keywordAuthor | curcumin | - |
dc.subject.keywordAuthor | anti-oxidant | - |
dc.subject.keywordAuthor | tumor migration | - |
dc.subject.keywordAuthor | tumor invasion | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
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