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Altered branching patterns of Purkinje cells in mouse model for cortical development disorder

Title
Altered branching patterns of Purkinje cells in mouse model for cortical development disorder
Authors
Jinkyung KimKwon, NChang, SKim, KTLee, DKim, SSojeong YunHwang, DKim, JWHwu, YMargaritondo, GJe, JHRhyu, IJ
POSTECH Authors
Hwang, DJe, JH
Date Issued
Oct-2011
Publisher
England,England,London : Nature Publishing Group, copyright
Abstract
Disrupted cortical cytoarchitecture in cerebellum is a typical pathology in reeler. Particularly interesting are structural problems at the cellular level: dendritic morphology has important functional implication in signal processing. Here we describe a combinatorial imaging method of synchrotron X-ray microtomography with Golgi staining, which can deliver 3-dimensional(3-D) micro-architectures of Purkinje cell(PC) dendrites, and give access to quantitative information in 3-D geometry. In reeler, we visualized in 3-D geometry the shape alterations of planar PC dendrites (i.e., abnormal 3-D arborization). Despite these alterations, the 3-D quantitative analysis of the branching patterns showed no significant changes of the 77 +/- 8 degrees branch angle, whereas the branch segment length strongly increased with large fluctuations, comparing to control. The 3-D fractal dimension of the PCs decreased from 1.723 to 1.254, indicating a significant reduction of dendritic complexity. This study provides insights into etiologies and further potential treatment options for lissencephaly and various neurodevelopmental disorders.
URI
http://oasis.postech.ac.kr/handle/2014.oak/16581
DOI
10.1038/SREP00122
ISSN
2045-2322
Article Type
Article
Citation
SCIENTIFIC REPORTS, vol. 1, 2011-10
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 HWANG, DAEHEE
Div of Integrative Biosci & Biotech
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