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dc.contributor.authorPark, Sko
dc.contributor.authorYang, JSko
dc.contributor.authorKim, Jko
dc.contributor.authorShin, YEko
dc.contributor.authorHwang, Jko
dc.contributor.authorPark, Jko
dc.contributor.authorJang, SKko
dc.contributor.authorKim, Sko
dc.date.available2016-03-31T08:51:18Z-
dc.date.created2013-02-01-
dc.date.issued2012-10-
dc.identifier.citationSCIENTIFIC REPORTS, v.2-
dc.identifier.issn2045-2322-
dc.identifier.other2012-OAK-0000026252-
dc.identifier.urihttp://oasis.postech.ac.kr/handle/2014.oak/16181-
dc.description.abstractThe extent to which evolutionary changes have impacted the phenotypic relationships among human diseases remains unclear. In this work, we report that phenotypically similar diseases are connected by the evolutionary constraints on human disease genes. Human disease groups can be classified into slowly or rapidly evolving classes, where the diseases in the slowly evolving class are enriched with morphological phenotypes and those in the rapidly evolving class are enriched with physiological phenotypes. Our findings establish a clear evolutionary connection between disease classes and disease phenotypes for the first time. Furthermore, the high comorbidity found between diseases connected by similar evolutionary constraints enables us to improve the predictability of the relative risk of human diseases. We find the evolutionary constraints on disease genes are a new layer of molecular connection in the network-based exploration of human diseases.-
dc.description.statementofresponsibilityX-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.titleEvolutionary history of human disease genes reveals phenotypic connections and comorbidity among genetic diseases-
dc.typeArticle-
dc.contributor.college정보전자융합공학부-
dc.identifier.doi10.1038/SREP00757-
dc.author.googlePark, S-
dc.author.googleYang, JS-
dc.author.googleKim, J-
dc.author.googleShin, YE-
dc.author.googleHwang, J-
dc.author.googlePark, J-
dc.author.googleJang, SK-
dc.author.googleKim, S-
dc.relation.volume2-
dc.contributor.id10136479-
dc.publisher.locationUK-
dc.relation.journalSCIENTIFIC REPORTS-
dc.relation.indexSCI급, SCOPUS 등재논문-
dc.relation.sciSCI-
dc.collections.nameJournal Papers-
dc.identifier.pid20217-
dc.type.rimsART-
dc.contributor.localauthorJang, SK-
dc.contributor.nonIdAuthorPark, S-
dc.contributor.nonIdAuthorYang, JS-
dc.contributor.nonIdAuthorKim, J-
dc.contributor.nonIdAuthorShin, YE-
dc.contributor.nonIdAuthorHwang, J-
dc.contributor.nonIdAuthorPark, J-
dc.contributor.nonIdAuthorKim, S-
dc.identifier.wosid000310449200003-
dc.citation.titleSCIENTIFIC REPORTS-
dc.citation.volume2-
dc.identifier.localId0000026252-
dc.identifier.localId0000026342-
dc.identifier.scopusid2-s2.0-84868278621-
dc.description.journalClass1-

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 JANG, SUNG KEY
Dept of Life Sciences
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