PD-L1이 trinitrobenzene sulfonic acid (TNBS) 유도 대장염에 미치는 영향에 관한 연구
- PD-L1이 trinitrobenzene sulfonic acid (TNBS) 유도 대장염에 미치는 영향에 관한 연구
- Date Issued
- The programmed death-1 (PD-1) receptor and programmed death-ligand 1 (PD-L1) pathway negatively regulates T cell activation and proliferation and promotes tolerance. Here, we find evidence that treatment using recombinant adenovirus expressing nonlytic Fc-conjugated PD-L1 (Ad/PD-L1-Fc) ameliorates CD-like colitis induced by TNBS in mice. Ad/PD-L1-Fc reduces the deleterious symptoms associated with colitis by preferentially binding to and inhibiting PD-1 expressing inflammatory Th17 cells in the gut. The reduction of Th17 cells is also associated with an increased protective Th1 response presumably due to their counter regulatory relationship. Thus, administration of Ad/PD-L1-Fc in TNBS colitic mice results in increased survival that is attributable to reduced weight loss and colon injury and may be a novel therapeutic method of treating CD-like colitis.
- Article Type
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.