Open Access System for Information Sharing

Login Library

 

Thesis
Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

PD-L1이 trinitrobenzene sulfonic acid (TNBS) 유도 대장염에 미치는 영향에 관한 연구

Title
PD-L1이 trinitrobenzene sulfonic acid (TNBS) 유도 대장염에 미치는 영향에 관한 연구
Authors
박한아이
Date Issued
2012
Publisher
포항공과대학교
Abstract
The programmed death-1 (PD-1) receptor and programmed death-ligand 1 (PD-L1) pathway negatively regulates T cell activation and proliferation and promotes tolerance. Here, we find evidence that treatment using recombinant adenovirus expressing nonlytic Fc-conjugated PD-L1 (Ad/PD-L1-Fc) ameliorates CD-like colitis induced by TNBS in mice. Ad/PD-L1-Fc reduces the deleterious symptoms associated with colitis by preferentially binding to and inhibiting PD-1 expressing inflammatory Th17 cells in the gut. The reduction of Th17 cells is also associated with an increased protective Th1 response presumably due to their counter regulatory relationship. Thus, administration of Ad/PD-L1-Fc in TNBS colitic mice results in increased survival that is attributable to reduced weight loss and colon injury and may be a novel therapeutic method of treating CD-like colitis.
URI
http://postech.dcollection.net/jsp/common/DcLoOrgPer.jsp?sItemId=000001384982
http://oasis.postech.ac.kr/handle/2014.oak/1606
Article Type
Thesis
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Views & Downloads

Browse