Open Access System for Information Sharing

Login Library

 

Article
Cited 22 time in webofscience Cited 26 time in scopus
Metadata Downloads

Enhanced endothelialization for developing artificial vascular networks with a natural vessel mimicking the luminal surface in scaffolds

Title
Enhanced endothelialization for developing artificial vascular networks with a natural vessel mimicking the luminal surface in scaffolds
Authors
Kang, TYHong, JMKim, BJCha, HJCho, DW
POSTECH Authors
Cha, HJCho, DW
Date Issued
Jan-2013
Publisher
ELSEVIER
Abstract
Large tissue regeneration remains problematic because of a lack of oxygen and nutrient supply. An attempt to meet the metabolic needs of cells has been made by preforming branched vascular networks within a scaffold to act as channels for mass transport. When constructing functional vascular networks with channel patency, emphasis should be placed on anti-thrombogenic surface issues. The aim of this study was to develop a rapid endothelialization method for creating an anti-thrombogenic surface mimicking the natural vessel wall in the artificial vascular networks. Shear stress preconditioning and scaffold surface modification were investigated as effective approaches for promoting biomaterial endothelialization. We found that a transient increase in shear stress at the appropriate time is key to enhancing endothelialization. Moreover, surface modification with bioactive materials such as collagen and recombinant mussel adhesive protein fused with arginine-glycine-aspartic acid peptide (MAP-RGD) showed a synergetic effect with shear stress preconditioning. Platelet adhesion tests demonstrated the anti-thrombogenic potential of MAP-RGD itself without endothelialization. The rapid endothelialization method established in this study can be easily applied to preformed artificial vascular networks in porous scaffolds. Development of artificial vascular networks with an anti-thrombogenic luminal surface will open up a new chapter in tissue engineering and regenerative medicine. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Keywords
Tissue engineering; Scaffold with artificial vascular networks; Shear stress precondition; Surface coating; Endothelialization; FLOW-CHANNEL NETWORK; CELL-ADHESION; IN-VITRO; PLATELET-ADHESION; SHEAR-STRESS; PERFUSION CULTURE; RGD-PEPTIDES; GRAFT; FABRICATION; MICROSTEREOLITHOGRAPHY
URI
http://oasis.postech.ac.kr/handle/2014.oak/15717
DOI
10.1016/J.ACTBIO.2012.08.042
ISSN
1742-7061
Article Type
Article
Citation
Acta Biomaterialia, vol. 9, no. 1, page. 4716 - 4725, 2013-01
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

 CHO, DONG WOO
Dept of Mechanical Enginrg
Read more

Views & Downloads

Browse