Open Access System for Information Sharing

Login Library

 

Article
Cited 6 time in webofscience Cited 7 time in scopus
Metadata Downloads

Acetyl salicylic acid inhibits Th17 airway inflammation via blockade of IL-6 and IL-17 positive feedback.

Title
Acetyl salicylic acid inhibits Th17 airway inflammation via blockade of IL-6 and IL-17 positive feedback.
Authors
Moon, HGKang, CSChoi, JPChoi, DSChoi, HIChoi, YWJeon, SGYoo, JYJang, MHGho, YSKim, YK
POSTECH Authors
Gho, YSKim, YK
Date Issued
Jan-2013
Publisher
Seoul : Korean Society of Medical Biochemistry and Molecular
Abstract
T-helper (Th) 17 cell responses are important for the development of neutrophilic inflammatory disease. Recently, we found that acetyl salicylic acid (ASA) inhibited Th17 airway inflammation in an asthma mouse model induced by sensitization with lipopolysaccharide (LPS)-containing allergens. To investigate the mechanism(s) of the inhibitory effect of ASA on the development of Th17 airway inflammation, a neutrophilic asthma mouse model was generated by intranasal sensitization with LPS plus ovalbumin (OVA) and then challenged with OVA alone. Immunologic parameters and airway inflammation were evaluated 6 and 48 h after the last OVA challenge. ASA inhibited the production of interleukin (IL)-17 from lung T cells as well as in vitro Th17 polarization induced by IL-6. Additionally, ASA, but not salicylic acid, suppressed Th17 airway inflammation, which was associated with decreased expression of acetyl-STAT3 (downstream signaling of IL-6) in the lung. Moreover, the production of IL-6 from inflammatory cells, induced by IL-17, was abolished by treatment with ASA, whereas that induced by LPS was not. Altogether, ASA, likely via its acetyl moiety, inhibits Th17 airway inflammation by blockade of IL-6 and IL-17 positive feedback. Experimental & Molecular Medicine (2013) 45, e5
doi:10.1038/emm.2013.10
published online 18 January 2013
Keywords
Acetyl salicylic acid; IL-6; IL-17A; STAT3; Th17; T-HELPER-CELLS; PROSTAGLANDIN SYNTHESIS; FAMILY CYTOKINES; DENDRITIC CELLS; KAPPA-B; STAT3; DISEASE; ASPIRIN; ASTHMA; INTERLEUKIN-17
URI
http://oasis.postech.ac.kr/handle/2014.oak/15323
DOI
10.1038/EMM.2013.10
ISSN
1226-3613
Article Type
Article
Citation
EXPERIMENTAL AND MOLECULAR MEDICINE, vol. 18, no. 45, page. E6, 2013-01
Files in This Item:

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

 GHO, YONG SONG
Dept of Life Sciences
Read more

Views & Downloads

Browse