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Detection of pH-induced aggregation of “smart” gold nanoparticles with photothermal optical coherence tomography

Title
Detection of pH-induced aggregation of “smart” gold nanoparticles with photothermal optical coherence tomography
Authors
Xiao, PQingyun LiJoo, YJutaek NamSekyu HwangJaejung SongKim, SChulmin JooKi Hean Kim
POSTECH Authors
Kim, S
Date Issued
Nov-2013
Publisher
OPTICAL SOC AMER
Abstract
We report the feasibility of a novel contrast agent, namely "smart" gold nanoparticles (AuNPs), in the detection of cancer cells with photothermal optical coherence tomography (PT-OCT). "Smart" AuNPs form aggregation in low pH condition, which is typical for cancer cells, and this aggregation results in a shift of their absorption spectrum. A PT-OCT system was developed to detect this pH-induced aggregation by combining an OCT light source and a laser with 660 nm in wavelength for photothermal excitation. Optical detection of pH-induced aggregation was tested with solution samples at two different pH conditions. An increase in optical path length (OPL) variation was measured at mild acidic condition, while there was not much change at neutral condition. Detection of cancer cells was tested with cultured cell samples. HeLa and fibroblast cells, as cancer and normal cells respectively, were incubated with "smart" gold nanoparticles and measured with PT-OCT. An elevated OPL variation signal was detected with the HeLa cells while not much of a signal was detected with the fibroblast cells. With the novel optical property of "smart" AuNPs and high sensitivity of PT-OCT, this technique is promising for cancer cell detection. (C) 2013 Optical Society of America
Keywords
GROWTH-FACTOR RECEPTOR; CANCER-THERAPY; OCT; MICE
URI
http://oasis.postech.ac.kr/handle/2014.oak/15096
DOI
10.1364/OL.38.004429
ISSN
0146-9592
Article Type
Article
Citation
OPTICS LETTERS, vol. 38, no. 21, page. 4429 - 4432, 2013-11
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 KIM, SUNG JEE
Dept of Chemistry
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