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3D Tissue Engineered Supramolecular Hydrogels for the Controlled Chondrogenesis of Human Mesenchymal Stem Cell

Title
3D Tissue Engineered Supramolecular Hydrogels for the Controlled Chondrogenesis of Human Mesenchymal Stem Cell
Authors
Jung, HPark, JSYeom, JSelvapalam, NPark, KMOh, KYang, JAPark, KHHAHN, SEI KWANGKim, K
POSTECH Authors
HAHN, SEI KWANGKim, K
Date Issued
Mar-2014
Publisher
AMER CHEMICAL SOC
Abstract
Despite a wide investigation of hydrogels as an artificial extracellular matrix, there are few scaffold systems for the facile spatiotemporal control of mesenchymal stem cells (MSCs). Here, we report 3D tissue engineered supramolecular hydrogels prepared with highly water-soluble monofunctionalized cucurbit[6]uril-hyaluronic acid (CB[6]-HA), diaminohexane conjugated HA (DAH-HA), and drug conjugated CB[6] (drug-CB[6]) for the controlled chondrogenesis of human mesenchymal stem cells (hMSCs). The mechanical property of supramolecular HA hydrogels was modulated by changing the cross-linking density for the spatial control of hMSCs. In addition, the differentiation of hMSCs was temporally controlled by changing the release profiles of transforming growth factor-beta 3 (TGF-beta 3) and/or dexamethasone (Dexa) from the hydrolyzable Dexa-CB[6]. The effective chondrogenic differentiation of hMSCs encapsulated in the monoCB[6]/DAH-HA hydrogel with TGF-beta 3 and Dexa-CB[6] was confirmed by biochemical glycosaminoglycan content analysis, real-time quantitative PCR, histological, and immunohistochemical analyses. Taken together, we could confirm the feasibility of cytocompatible monoCB[6]/DAH-HA hydrogels as a platform scaffold with controlled drug delivery for cartilage regeneration and other various tissue engineering applications.
URI
http://oasis.postech.ac.kr/handle/2014.oak/14073
DOI
10.1021/BM401123M
ISSN
1525-7797
Article Type
Article
Citation
BIOMACROMOLECULES, vol. 15, no. 3, page. 707 - 714, 2014-03
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 KIM, KIMOON
Dept of Chemistry
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