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dc.contributor.authorKim, Hko
dc.contributor.authorPark, HTko
dc.contributor.authorTae, YMko
dc.contributor.authorKong, WHko
dc.contributor.authorSung, DKko
dc.contributor.authorHwang, BWko
dc.contributor.authorKim, KSko
dc.contributor.authorKim, YKko
dc.contributor.authorHahn, SKko
dc.date.available2016-03-31T07:40:18Z-
dc.date.created2014-02-07-
dc.date.issued2013-11-
dc.identifier.citationBIOMATERIALS, v.34, no.33, pp.8478 - 8490-
dc.identifier.issn0142-9612-
dc.identifier.other2013-OAK-0000031566-
dc.identifier.urihttp://oasis.postech.ac.kr/handle/2014.oak/13886-
dc.description.abstractDespite wide exploitation of corticosteroid drugs for the treatment of asthma, the poor therapeutic effect on a neutrophilic subtype of asthma prohibits the full recovery of asthma patients. In this work, dexamethasone (Dexa) was loaded in Flt1 peptide-hyaluronic acid (HA) conjugate nanoparticles to overcome the limitation of corticosteroid resistance for the treatment of neutrophilic pulmonary inflammation. Fin peptide-HA conjugates are self-assembled to nanoparticles because of hydrophobic Flt1 peptide conjugated to HA by benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP) chemistry. In vitro bioimaging showed efficient internalization of Fin peptide-HA conjugate nanoparticles into lung epithelial cells by HA-receptor mediated endocytosis. Also, ex vivo imaging for the biodistribution in ICR mice revealed long-term retention of Flt1 peptide-HA conjugate nanoparticles in deep lung tissues possibly due to mucoadhesive property of HA. On the basis of bioimaging results for pulmonary drug delivery applications, we prepared Dexa-loaded Flt1 peptide-HA conjugate nanoparticles. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) confirmed the formation of nanoparticles, which reduced cytokine levels of lipopolysaccharide (LPS)-stimulated cells more efficiently than free Dexa. Furthermore, according to the bronchoalveolar lavage (BAL) cellularity and histological analysis, Dexa loaded Flt1 peptide-HA conjugate nanoparticles showed remarkable therapeutic effects in both eosinophilic and neutrophilic asthma model mice. (C) 2013 Elsevier Ltd. All rights reserved.-
dc.description.statementofresponsibilityX-
dc.languageEnglish-
dc.publisherELSEVIER SCI LTD-
dc.subjectHyaluronic acid-
dc.subjectFlt1 peptide-
dc.subjectDexamethasone-
dc.subjectNanoparticle-
dc.subjectPulmonary delivery-
dc.subjectAsthma-
dc.subjectENDOTHELIAL GROWTH-FACTOR-
dc.subjectANTI-FLT1 PEPTIDE-
dc.subjectLUNG INJURY-
dc.subjectASTHMA-
dc.subjectDELIVERY-
dc.subjectRECEPTOR-
dc.subjectTYPE-1-
dc.subjectCELLS-
dc.subjectNEOVASCULARIZATION-
dc.subjectPOLARIZATION-
dc.titleBioimaging and pulmonary applications of self-assembled Flt1 peptide-hyaluronic acid conjugate nanoparticles-
dc.typeArticle-
dc.contributor.college생명과학과-
dc.identifier.doi10.1016/J.BIOMATERIALS.2013.07.062-
dc.author.googleKim, H-
dc.author.googlePark, HT-
dc.author.googleTae, YM-
dc.author.googleKong, WH-
dc.author.googleSung, DK-
dc.author.googleHwang, BW-
dc.author.googleKim, KS-
dc.author.googleKim, YK-
dc.author.googleHahn, SK-
dc.relation.volume34-
dc.relation.issue33-
dc.relation.startpage8478-
dc.relation.lastpage8490-
dc.contributor.id10103891-
dc.publisher.locationUK-
dc.relation.journalBIOMATERIALS-
dc.relation.indexSCI급, SCOPUS 등재논문-
dc.relation.sciSCI-
dc.collections.nameJournal Papers-
dc.type.rimsART-
dc.contributor.localauthorKim, YK-
dc.contributor.localauthorHahn, SK-
dc.contributor.nonIdAuthorKim, H-
dc.contributor.nonIdAuthorPark, HT-
dc.contributor.nonIdAuthorTae, YM-
dc.contributor.nonIdAuthorKong, WH-
dc.contributor.nonIdAuthorSung, DK-
dc.contributor.nonIdAuthorHwang, BW-
dc.contributor.nonIdAuthorKim, KS-
dc.identifier.wosid000324720700048-
dc.date.tcdate2019-01-01-
dc.citation.endPage8490-
dc.citation.number33-
dc.citation.startPage8478-
dc.citation.titleBIOMATERIALS-
dc.citation.volume34-
dc.identifier.scopusid2-s2.0-84881664035-
dc.description.journalClass1-
dc.description.wostc13-
dc.description.scptc14*
dc.date.scptcdate2018-05-121*

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 HAHN, SEI KWANG
Dept of Materials Science & Enginrg
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