Development of Novel Fluorescent Nucleic Acid Systems to Probe DNA Quadruplex Structures
- Development of Novel Fluorescent Nucleic Acid Systems to Probe DNA Quadruplex Structures
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Nucleic acid today can be viewed as a chemical reagent, quite apart from its role in biology, although much of the work is inspired by what might be the positive consequences for medicine or drug development or diagnosis of disease. For even neglecting its biological importance, there would still be a lot of interests in nucleic acid as a fundamental molecule for chemists to study and use as an object for chemical building blocks, sensing, polymer design and others.
Nowadays, nucleic acids have been emerged from various research areas such as DNA computing, nano-size structures using DNA, sensors recognizing mRNA and DNA, and oligonucleotide therapeutics, and others. Chemical modification of nucleic acid systems is essential to obtain more effective and stable materials. From nucleoside to oligonucleotide, chemical modification is open to any part of nucleic acid. The topics of this thesis focus on the synthesis of new phosphoramidites to incorporate into the oligonucleotides and to investigate the quadruplex structures.
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