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DNA hydrogel delivery vehicle for light-triggered and synergistic cancer therapy

Title
DNA hydrogel delivery vehicle for light-triggered and synergistic cancer therapy
Authors
Song, JIm, KHwang, SHur, JNam, JAhn, GOHwang, SKim, SPark, N
POSTECH Authors
Ahn, GOKim, S
Date Issued
Jan-2015
Publisher
ROYAL SOC CHEMISTRY
Abstract
A DNA hydrogel is reported as a delivery vehicle for gold nanorods and doxorubicin. The two photothermal and chemo cancer agents were co-loaded using electrostatic and DNA binding interactions, respectively. Light-triggered and highly synergistic combination cancer therapy was demonstrated in cellular and animal models.
Keywords
GOLD NANORODS; PHOTOTHERMAL THERAPY; DRUG-RELEASE; NANOPARTICLES; HYPERTHERMIA; DOXORUBICIN; ADRIAMYCIN; STABILITY; TOXICITY; UPDATE
URI
http://oasis.postech.ac.kr/handle/2014.oak/13339
DOI
10.1039/C5NR00858A
ISSN
2040-3364
Article Type
Article
Citation
NANOSCALE, vol. 7, no. 21, page. 9433 - 9437, 2015-01
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 KIM, SUNG JEE
Dept of Chemistry
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