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Light-responsible DNA hydrogel–gold nanoparticle assembly for synergistic cancer therapy

Title
Light-responsible DNA hydrogel–gold nanoparticle assembly for synergistic cancer therapy
Authors
Jaejung SongSungwoo HwangKyuhyun ImJaehyun HurJutaek NamHwang, SAhn, GOKim, SNokyoung Park
POSTECH Authors
Ahn, GOKim, S
Date Issued
Jan-2015
Publisher
ROYAL SOC CHEMISTRY
Abstract
Assembled AuNPs in a DNA hydrogel (Dgel) showed strongly coupled plasmon modes, and the Dgel vehicle can co-load anticancer drugs such as doxorubicin (Dox) as a light-controlled releasing cargo by DNA intercalations. Upon laser excitation, local heat shock generation was accompanied by the release of Dox. A highly synergistic combination of thermo- and chemotherapy was demonstrated in cellular and animal models. Our Dgel vehicle can be fragmented after the excitation-induced heat generations, which subsequently causes the dispersion of the AuNPs. Our system may be less toxic because it uses small sizes of AuNPs, and the inherently biocompatible scaffold may reduce the long-term toxicity by rapid clearance.
Keywords
PHOTOTHERMAL THERAPY; DRUG-RELEASE; HYPERTHERMIA; DOXORUBICIN; CELLS
URI
http://oasis.postech.ac.kr/handle/2014.oak/13058
DOI
10.1039/C4TB01519C
ISSN
2050-750X
Article Type
Article
Citation
JOURNAL OF MATERIALS CHEMISTRY B, vol. 3, no. 8, page. 1537 - 1543, 2015-01
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 KIM, SUNG JEE
Dept of Chemistry
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