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Ratiometric fluorescence detection of cysteine and homocysteine with a BODIPY dye by mimicking the native chemical ligation

Title
Ratiometric fluorescence detection of cysteine and homocysteine with a BODIPY dye by mimicking the native chemical ligation
Authors
Ma, DHKim, D안교한Ahn, KHLee, SJSeo, E
Date Issued
Jan-2015
Publisher
ROYAL SOC CHEMISTRY
Abstract
The selective detection of cysteine and homocysteine over glutathione and other amino acids was demonstrated with an 8-MeS-BODIPY probe by mimicking the native chemical ligation approach, which allowed the selective and ratiometric fluorescence sensing of cysteine over other biothiols at physiologically relevant concentrations and in different organs of a zebrafish.
Keywords
LARGE EMISSION SHIFT; HIGHLY SELECTIVE DETECTION; CHEMODOSIMETER; SENSOR; DISEASE; MECHANISM; GLUTATHIONE; THIOL PROBE; OXIDATIVE STRESS; LIVING CELLS
URI
http://oasis.postech.ac.kr/handle/2014.oak/13023
DOI
10.1039/c4an01791a
ISSN
0003-2654
Article Type
ARTICLE
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