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시스템 생물 정보학을 이용한 세포 막 단백질의 기능 다양성 연구

시스템 생물 정보학을 이용한 세포 막 단백질의 기능 다양성 연구
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Cells can respond to environment by sensing and translating extracellular signals to stimulate internal responses that lead to changes in gene expression and phenotypic alterations. Plasma membrane proteins accept and transmit a variety of extracellular signals so that structural diversity is necessary to achieve functional diversity. However, plasma membrane proteins happen to fall into fewer families and folds compared to soluble proteins and how such functional diversity was achieved for plasma membrane proteins is need to be understood. Here, we investigated the interplay among subcellular localizations, tissue specific expression and protein-protein interaction network and found that dynamic rewiring of protein-protein interactions is the key process to obtain the functional diversity of the plasma membrane proteins. To reveal this, we analyzed 11,043 human transcripts across 79 different tissues. Plasma membrane proteins were found to be co-expressed with their interacting partners in a fewer number of tissues than other subcellular localizations and their partners were different in each tissues. Moreover, we measured diversity of function of partners for each protein and found that partners of plasma membrane proteins have different function annotation, which perform different function if their partners are changed by expression regulation. Our result suggest that alternative expressions of interacting partners could lead to rewire protein-protein interactions under different tissue conditions, which would provide the key mechanism to achieve functional diversity for adapting to tissue specific environment.
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