Open Access System for Information Sharing

Login Library

 

Article
Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Preparation of Doxorubicin-Loaded Amphiphilic Poly(D,L-Lactide-Co-Glycolide)-b-Poly(N-Acryloylmorpholine) AB(2)Miktoarm Star Block Copolymers for Anticancer Drug Delivery

Title
Preparation of Doxorubicin-Loaded Amphiphilic Poly(D,L-Lactide-Co-Glycolide)-b-Poly(N-Acryloylmorpholine) AB(2)Miktoarm Star Block Copolymers for Anticancer Drug Delivery
Authors
Ramesh, KalyanMishra, Avnish KumarKim, Jin KonJeong, Yeon TaeGal, Yeong-SoonLim, Kwon Taek
Date Issued
Sep-2020
Publisher
MDPI Open Access Publishing
Abstract
Owing to their unique topology and physical properties, micelles based on miktoarm amphiphilic star block copolymers play an important role in the biomedical field for drug delivery. Herein, we developed a series of AB(2)-type poly(D,L-lactide-co-glycolide)-b-poly(N-acryloyl morpholine) (PLGA-b-PNAM(2)) miktoarm star block copolymers by reversible addition-fragmentation chain-transfer polymerization and ring-opening copolymerization. The resulting miktoarm star polymers were investigated by(1)H NMR spectroscopy and gel permeation chromatography. The critical micellar concentration value of the micelles increases with an increase in PNAM block length. As revealed by transmission electron microscopy and dynamic light scattering, the amphiphilic miktoarm star block copolymers can self-assemble to form spherical micellar aggregates in water. The anticancer drug doxorubicin (DOX) was encapsulated by polymeric micelles; the drug-loading efficiency and drug-loading content of the DOX-loaded micelles were 81.7% and 9.1%, respectively. Acidic environments triggered the dissociation of the polymeric micelles, which led to the more release of DOX in pH 6.4 than pH 7.4. The amphiphilic PLGA-b-PNAM(2)miktoarm star block copolymers may have broad application as nanocarriers for controlled drug delivery.
URI
http://oasis.postech.ac.kr/handle/2014.oak/104631
ISSN
1996-1944
Article Type
Article
Citation
Materials, vol. 13, no. 17, 2020-09
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

김진곤KIM, JIN KON
Dept. of Chemical Enginrg
Read more

Views & Downloads

Browse