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A rationally designed polarity-viscosity sensitive probe for imaging lipid droplets

Title
A rationally designed polarity-viscosity sensitive probe for imaging lipid droplets
Authors
Song, C.W.Tamima, U.Reo, Y.J.Dai, M.Sarkar, S.Ahn, K.H.
Date Issued
Dec-2019
Publisher
ELSEVIER SCI LTD
Abstract
Playing central roles in energy homeostasis and lipid metabolism, lipid droplets (LDs) also contribute to cellular protein trafficking and maturation and are associated with several human diseases. A dozen of fluorescent probes are known so far, and most of them sense either the less polar or the more viscous environment of LDs compared to that of cytosol. Described herein is a rational approach to the deep-red emitting LD probe that senses both the nonpolar and highly viscous environment of LDs. This dual sensing probe is chemically stable, not responding to typical biothiols and reactive oxygen species, and also photochemically stable suitable for long-term monitoring of LDs. The probe is proven to be efficient for the detection of LDs, as demonstrated by several in cellulo imaging experiments for HeLa cells under starvation and under an excess level of oleic acid, and also for 3T3-L1 cells that differentiate into an adipocyte-like phenotype.
URI
http://oasis.postech.ac.kr/handle/2014.oak/100286
ISSN
0143-7208
Article Type
Article
Citation
DYES AND PIGMENTS, vol. 171, 2019-12
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 AHN, KYO HAN
Dept of Chemistry
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